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locally estimated scatterplot smoothing regression  (RStudio)
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RStudio locally estimated scatterplot smoothing regression
Pharmacokinetic curves of moxifloxacin with and without rifampicin coadministration of in‐house collected therapeutic drug monitoring (TDM) data for 400 mg of moxifloxacin only (A), 400 mg moxifloxacin with any dose of rifampicin (B), and 600 mg of moxifloxacin with any dose of rifampicin (C); median rifampicin dose for both group B and C was 1200 mg once daily (range, 450‐2000 mg). The x‐axis indicates time after last dose. Open circles and crosses indicate measured individual data from in‐house TDM data of patients with Mycobacterium tuberculosis or nontuberculous mycobacteria infections, respectively; the solid black lines indicate the fitted plasma concentration‐time curve using locally estimated <t>scatterplot</t> smoothing regression; and the gray area represents the 95% confidence interval around the regression. AUC 0‐24 , area under the plasma concentration–time curve from time 0 to 24 hours; C max , maximum plasma concentration.
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Pharmacokinetic curves of moxifloxacin with and without rifampicin coadministration of in‐house collected therapeutic drug monitoring (TDM) data for 400 mg of moxifloxacin only (A), 400 mg moxifloxacin with any dose of rifampicin (B), and 600 mg of moxifloxacin with any dose of rifampicin (C); median rifampicin dose for both group B and C was 1200 mg once daily (range, 450‐2000 mg). The x‐axis indicates time after last dose. Open circles and crosses indicate measured individual data from in‐house TDM data of patients with Mycobacterium tuberculosis or nontuberculous mycobacteria infections, respectively; the solid black lines indicate the fitted plasma concentration‐time curve using locally estimated scatterplot smoothing regression; and the gray area represents the 95% confidence interval around the regression. AUC 0‐24 , area under the plasma concentration–time curve from time 0 to 24 hours; C max , maximum plasma concentration.

Journal: Journal of Clinical Pharmacology

Article Title: Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling

doi: 10.1002/jcph.1972

Figure Lengend Snippet: Pharmacokinetic curves of moxifloxacin with and without rifampicin coadministration of in‐house collected therapeutic drug monitoring (TDM) data for 400 mg of moxifloxacin only (A), 400 mg moxifloxacin with any dose of rifampicin (B), and 600 mg of moxifloxacin with any dose of rifampicin (C); median rifampicin dose for both group B and C was 1200 mg once daily (range, 450‐2000 mg). The x‐axis indicates time after last dose. Open circles and crosses indicate measured individual data from in‐house TDM data of patients with Mycobacterium tuberculosis or nontuberculous mycobacteria infections, respectively; the solid black lines indicate the fitted plasma concentration‐time curve using locally estimated scatterplot smoothing regression; and the gray area represents the 95% confidence interval around the regression. AUC 0‐24 , area under the plasma concentration–time curve from time 0 to 24 hours; C max , maximum plasma concentration.

Article Snippet: Individual plasma concentrations were plotted against time and a plasma concentration‐time curve was fitted using locally estimated scatterplot smoothing regression in R Studio version 1.1.463 (RStudio, Inc, Boston, Massachusetts) after which a C max was determined.

Techniques: Clinical Proteomics, Concentration Assay